Drug

Site of Action

Mutation in gene

Isoniazid

Mycolic acid synthesis

katG, inhA, acpM, kasA

Rifampicin

RNA synthesis

Rpoβ

Streptomycin

Ribosomal S2 protein

rpsL

Pyrazinamide

Pyrazinamidase enzyme

pncA

Ethambutol

Arabinosyltransferase enzyme

embB

Kanamycin

16S rRNA

Rrs

Ethionamide

Mycolic acid synthesis

etaA