Drug | Site of Action | Mutation in gene |
Isoniazid | Mycolic acid synthesis | katG, inhA, acpM, kasA |
Rifampicin | RNA synthesis | Rpoβ |
Streptomycin | Ribosomal S2 protein | rpsL |
Pyrazinamide | Pyrazinamidase enzyme | pncA |
Ethambutol | Arabinosyltransferase enzyme | embB |
Kanamycin | 16S rRNA | Rrs |
Ethionamide | Mycolic acid synthesis | etaA |